Stalfate-O is a locally acting substance that in an acidic environment (pH < 40) reacts with hydrochloric acid in the stomach to form a cross-linking, viscous, paste-like material capable of acting as an acid buffer for as long as 6 to 8 hours after a single dose. These complexes serve as protective barriers at the ulcer surface, preventing further damage from acid, pepsin, and bile. Stalfate-O also stimulates the increase of prostaglandin E2, epidermal growth factors(EGF), bFGF, and gastric mucus. The O stands for Oxetacaine which is a local anesthetic.
After oral administration, the sucralfate in Stalfate-O reacts with hydrochloric acid in the stomach to form a paste-like complex that will bind to the proteinaceous exudates that generally are found at ulcer sites. This insoluble complex forms a barrier at the site and protects the ulcer from further damage caused by pepsin, acid or bile.